PROJECT FUNDING: DFG
ABSTRACT:
During mitosis, sister chromatids connect to microtubules extending from the
opposite spindle poles via kinetochores, protein complexes on the chromosome. When a
pair of sister kinetochores establishes this configuration, they oscillate around
the equatorial plane of the spindle, and the amplitude of these oscillations depends
on kinesin-8 motors. During the oscillations sister kinetochores are separated due
to tension, which has been proposed to regulate the spindle assembly checkpoint. The
aim of this project is to study the mechanism of kinetochore oscillations.
PI and CO-PI
Iva Tolić i Nenad Pavin
COLLABORATORS:
Agneza Bosilj, Marcel Prelogović, Anna Klemm
KEYWORDS:
kinetochores, kinesin-8, microscopy, theoretical modeling